Guowen Wang M.D. Ph.D.
Director

Education

2006-2008, Postdoctoral fellow, Peking University, Beijing, China.
2003-2006, Ph.D., Harbin Medical University, Harbin, China
1996-1999 Master, Harbin Medical University, Harbin, China
1985-1990 B.S., Norman Bethune University of Medical Science, Changchun, China
Career

2008 – Present Director, Bone and Soft Tissue Oncology, Tianjin Medical University Cancer Hospital, Tianjin, China.

2006-2008 Postdoctoral fellow, People's Hospital Bone Tumor Center, Peking University. Beijing, China.

2001-2006 Associate Chief Surgeon, Department of Orthopedics, The Second Affiliated Hospital, Harbin Medical University, Harbin, China

1996-2001 Attending Surgeon, Department of Orthopedics, The Second Affiliated Hospital, Harbin Medical University, Harbin, China

1990-1996 Resident Surgeon, Department of Orthopedics, The First Affiliated Hospital, Harbin Medical University, Harbin, China Harbin, China.

Editorial Service

1.  “Advanced Therapy in Surgical Oncology” Translator, People's Medical Publishing House, 2018

2. “TNM Staging Atlas” Translator, Tianjin science and technology translation publishing co., 2016.

3. “The knowledge of sarcoma” deputy editor, Tianjin science and technology translation publishing co., 2016.

4. "Map of orthopedic surgery" deputy editor, People's Health Press, 2008

5. "New Practical Orthopedics" Military Medical Sciences institute has supervised the writing of 2008, "the application of nanotechnology in orthopedic"

Publications (updating) 

1. Zhang C, Xu G, Liu Z, Xu Y, Lin F, Baklaushev VP, Chekhonin VP, Peltzer K, Mao M, Wang X, Wang G, Zhang C. Epidemiology, tumor characteristics and survival in patients with angiosarcoma in the United States: a population-based study of 4537 cases. Jpn J Clin Oncol. 2019 Oct 15. [Epub ahead of print].
2. Zhang C, Mao M, Guo X, Cui P, Zhang L, Xu Y, Li L, Han X, Peltzer K, Xiong S, Baklaushev VP, Wang X, Wang G. Nomogram based on homogeneous and heterogeneous associated factors for predicting bone metastases in patients with different histological types of lung cancer. BMC Cancer. 2019;19(1):238.
3. Han X, Liu F, Zhang C, Ren Z, Li L, Wang G. SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells. Biol Chem. 2019;400(4):545-553.
4. Liu F, Li L, Li Y, Ma X, Bian X, Liu X, Wang G, Zhang D. Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV. Int J Oncol. 2018;53(5):2010-2020.
5. Zhang Y, Hu Q, Li G, Li L, Liang S, Zhang Y, Liu J, Fan Z, Li L, Zhou B, Ruan Y, Yang X, Chen S, Mu T, Wang G, Xiong S. ONZIN Upregulation by Mutant p53 Contributes to Osteosarcoma Metastasis Through the CXCL5-MAPK Signaling Pathway. Cell Physiol Biochem. 2018;48(3):1099-1111.
6. Guo X, Zhang C, Guo Q, Xu Y, Feng G, Li L, Han X, Lu F, Ma Y, Wang X, Wang G. The homogeneous and heterogeneous risk factors for the morbidity and prognosis of bone metastasis in patients with prostate cancer. Cancer Manag Res. 2018;10:1639-1646.
7. Chi Y, Fang Z, Hong X, Yao Y, Sun P, Wang G, Du F, Sun Y, Wu Q, Qu G, Wang S, Song J, Yu J, Lu Y, Zhu X, Niu X, He Z, Wang J, Yu H, Cai J. Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma. Clin Cancer Res. 2018;24(21):5233-5238.
Research Foundation

1. The mechanism of ONZIN expression in promoting osteosarcoma metastasis and its role in tumor immune response. National Natural Science Foundation of China (81872184)

2. The role of the Sox9 gene in dedifferentiated chondrosarcoma. National Natural Science Foundation of China (0700838)

3. The apoptosis and P53 expression in fibrosarcoma after hyperthermia. Heilongjiang Province Natural Science Foundation (D00-46)

Professional Affiliations

1. Deputy Director, Bone tumor group, Oncology Branch of Tianjin Medical Association.

2. Active member, Professional Committee of bone metastatic cancer, the sarcoma association of China Anti-Cancer Association.

3. Active member, Professional Committee of osteoporosis, Chinese gerontological Society.

4. Active member, Professional Committee of trauma, the Chinese Association of Rehabilitation Medicine.